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Regulatory Light Chain Mutations Associated with Cardiomyopathy Affect Myosin Mechanics and Kinetics

The myosin regulatory light chain (RLC) wraps around the alpha helical neck region of myosin. This neck region has been proposed to act as a lever arm, amplifying small conformational changes in the myosin head to generate motion. The RLC serves an important structural role, supporting the myosin ne...

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Detalhes bibliográficos
Main Authors: Greenberg, Michael J., Watt, James D., Jones, Michelle, Kazmierczak, Katarzyna, Szczesna-Cordary, Danuta, Moore, Jeffrey R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2675789/
https://ncbi.nlm.nih.gov/pubmed/18929571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2008.09.126
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