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Myosin regulatory light chain phosphorylation enhances cardiac β-myosin in vitro motility under load

Familial hypertrophic cardiomyopathy (HCM) is characterized by left ventricular hypertrophy and myofibrillar disarray, and often results in sudden cardiac death. Two HCM mutations, N47K and R58Q, are located in the myosin regulatory light chain (RLC). The RLC mechanically stabilizes the myosin lever...

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Bibliografiske detaljer
Udgivet i:Arch Biochem Biophys
Main Authors: Karabina, Anastasia, Kazmierczak, Katarzyna, Szczesna-Cordary, Danuta, Moore, Jeffrey R.
Format: Artigo
Sprog:Inglês
Udgivet: 2015
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4790447/
https://ncbi.nlm.nih.gov/pubmed/26116789
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.abb.2015.06.014
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