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Gene expression patterns in transgenic mouse models of hypertrophic cardiomyopathy caused by mutations in myosin regulatory light chain()

Using microarray and bioinformatics, we examined the gene expression profiles in transgenic mouse hearts expressing mutations in the myosin regulatory light chain shown to cause hypertrophic cardiomyopathy (HCM). We focused on two malignant RLC-mutations, Arginine 58→Glutamine (R58Q) and Aspartic Ac...

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Detalhes bibliográficos
Publicado no:Arch Biochem Biophys
Main Authors: Huang, Wenrui, Kazmierczak, Katarzyna, Zhou, Zhiqun, Aguiar-Pulido, Vanessa, Narasimhan, Giri, Szczesna-Cordary, Danuta
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5370580/
https://ncbi.nlm.nih.gov/pubmed/26906074
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.abb.2016.02.022
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