Furanyl-Rhodanines Are Unattractive Drug Candidates for Development as Inhibitors of Bacterial RNA Polymerase

Previous studies suggest that furanyl-rhodanines might specifically inhibit bacterial RNA polymerase (RNAP). We further explored three compounds from this class. Although they inhibited RNAP, each compound also inhibited malate dehydrogenase and chymotrypsin. Using biosensors responsive to inhibitio...

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Hlavní autoři: Mariner, Katherine R., Trowbridge, Rachel, Agarwal, Anil K., Miller, Keith, O'Neill, Alex J., Fishwick, Colin W. G., Chopra, Ian
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology (ASM) 2010
Témata:
Mechanisms of Action: Physiological Effects
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2944609/
https://ncbi.nlm.nih.gov/pubmed/20660693
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00753-10
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