Furanyl-Rhodanines Are Unattractive Drug Candidates for Development as Inhibitors of Bacterial RNA Polymerase

Previous studies suggest that furanyl-rhodanines might specifically inhibit bacterial RNA polymerase (RNAP). We further explored three compounds from this class. Although they inhibited RNAP, each compound also inhibited malate dehydrogenase and chymotrypsin. Using biosensors responsive to inhibitio...

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Detalhes bibliográficos
Main Authors: Mariner, Katherine R., Trowbridge, Rachel, Agarwal, Anil K., Miller, Keith, O'Neill, Alex J., Fishwick, Colin W. G., Chopra, Ian
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2010
Assuntos:
Mechanisms of Action: Physiological Effects
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2944609/
https://ncbi.nlm.nih.gov/pubmed/20660693
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00753-10
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