Activity of and Development of Resistance to Corallopyronin A, an Inhibitor of RNA Polymerase

We explored the properties of corallopyronin A (CorA), a poorly characterized inhibitor of bacterial RNA polymerase (RNAP). It displayed a 50% inhibitory concentration of 0.73 μM against RNAP, compared with 11.5 nM for rifampin. The antibacterial activity of CorA was also inferior to rifampin, and r...

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Bibliografiske detaljer
Main Authors: Mariner, Katherine, McPhillie, Martin, Trowbridge, Rachel, Smith, Catriona, O'Neill, Alex J., Fishwick, Colin W. G., Chopra, Ian
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2011
Fag:
Mechanisms of Resistance
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3088244/
https://ncbi.nlm.nih.gov/pubmed/21321139
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01742-10
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