Analysis of Mupirocin Resistance and Fitness in Staphylococcus aureus by Molecular Genetic and Structural Modeling Techniques

Chromosomal resistance to mupirocin in clinical isolates of Staphylococcus aureus arises from V(588)F or V(631)F mutations in isoleucyl-tRNA synthetase (IRS). Whether these are the only IRS mutations that confer mupirocin resistance or simply those that survive in the clinic is unknown. Mupirocin-re...

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Bibliografiske detaljer
Main Authors: Hurdle, Julian Gregston, O'Neill, Alexander John, Ingham, Eileen, Fishwick, Colin, Chopra, Ian
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2004
Fag:
Mechanisms of Resistance
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC525403/
https://ncbi.nlm.nih.gov/pubmed/15504866
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.48.11.4366-4376.2004
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