Analysis of Mupirocin Resistance and Fitness in Staphylococcus aureus by Molecular Genetic and Structural Modeling Techniques

Chromosomal resistance to mupirocin in clinical isolates of Staphylococcus aureus arises from V(588)F or V(631)F mutations in isoleucyl-tRNA synthetase (IRS). Whether these are the only IRS mutations that confer mupirocin resistance or simply those that survive in the clinic is unknown. Mupirocin-re...

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Bibliografische gegevens
Hoofdauteurs: Hurdle, Julian Gregston, O'Neill, Alexander John, Ingham, Eileen, Fishwick, Colin, Chopra, Ian
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Microbiology 2004
Onderwerpen:
Mechanisms of Resistance
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC525403/
https://ncbi.nlm.nih.gov/pubmed/15504866
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.48.11.4366-4376.2004
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