Analysis of Mupirocin Resistance and Fitness in Staphylococcus aureus by Molecular Genetic and Structural Modeling Techniques

Chromosomal resistance to mupirocin in clinical isolates of Staphylococcus aureus arises from V(588)F or V(631)F mutations in isoleucyl-tRNA synthetase (IRS). Whether these are the only IRS mutations that confer mupirocin resistance or simply those that survive in the clinic is unknown. Mupirocin-re...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Hurdle, Julian Gregston, O'Neill, Alexander John, Ingham, Eileen, Fishwick, Colin, Chopra, Ian
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2004
Assuntos:
Mechanisms of Resistance
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC525403/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15504866/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.48.11.4366-4376.2004
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