Furanyl-Rhodanines Are Unattractive Drug Candidates for Development as Inhibitors of Bacterial RNA Polymerase

Previous studies suggest that furanyl-rhodanines might specifically inhibit bacterial RNA polymerase (RNAP). We further explored three compounds from this class. Although they inhibited RNAP, each compound also inhibited malate dehydrogenase and chymotrypsin. Using biosensors responsive to inhibitio...

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Bibliografiske detaljer
Main Authors: Mariner, Katherine R., Trowbridge, Rachel, Agarwal, Anil K., Miller, Keith, O'Neill, Alex J., Fishwick, Colin W. G., Chopra, Ian
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2010
Fag:
Mechanisms of Action: Physiological Effects
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2944609/
https://ncbi.nlm.nih.gov/pubmed/20660693
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00753-10
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