Furanyl-Rhodanines Are Unattractive Drug Candidates for Development as Inhibitors of Bacterial RNA Polymerase

Previous studies suggest that furanyl-rhodanines might specifically inhibit bacterial RNA polymerase (RNAP). We further explored three compounds from this class. Although they inhibited RNAP, each compound also inhibited malate dehydrogenase and chymotrypsin. Using biosensors responsive to inhibitio...

Full description

Saved in:
Bibliographic Details
Main Authors: Mariner, Katherine R., Trowbridge, Rachel, Agarwal, Anil K., Miller, Keith, O'Neill, Alex J., Fishwick, Colin W. G., Chopra, Ian
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2010
Subjects:
Mechanisms of Action: Physiological Effects
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2944609/
https://ncbi.nlm.nih.gov/pubmed/20660693
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00753-10
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items