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Incorporation of pseudouridine into mRNA enhances translation by diminishing PKR activation
Previous studies have shown that the translation level of in vitro transcribed messenger RNA (mRNA) is enhanced when its uridines are replaced with pseudouridines; however, the reason for this enhancement has not been identified. Here, we demonstrate that in vitro transcripts containing uridine acti...
में बचाया:
| मुख्य लेखकों: | , , , , , , |
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| स्वरूप: | Artigo |
| भाषा: | Inglês |
| प्रकाशित: |
Oxford University Press
2010
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| विषय: | |
| ऑनलाइन पहुंच: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2943593/ https://ncbi.nlm.nih.gov/pubmed/20457754 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkq347 |
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