A carregar...
Generating the optimal mRNA for therapy: HPLC purification eliminates immune activation and improves translation of nucleoside-modified, protein-encoding mRNA
In vitro-transcribed mRNA has great therapeutic potential to transiently express the encoded protein without the adverse effects of viral and DNA-based constructs. Mammalian cells, however, contain RNA sensors of the innate immune system that must be considered in the generation of therapeutic RNA....
Na minha lista:
| Main Authors: | , , , |
|---|---|
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2011
|
| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3241667/ https://ncbi.nlm.nih.gov/pubmed/21890902 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkr695 |
| Tags: |
Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!
|