Incorporation of pseudouridine into mRNA enhances translation by diminishing PKR activation

Previous studies have shown that the translation level of in vitro transcribed messenger RNA (mRNA) is enhanced when its uridines are replaced with pseudouridines; however, the reason for this enhancement has not been identified. Here, we demonstrate that in vitro transcripts containing uridine acti...

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Detalhes bibliográficos
Main Authors: Anderson, Bart R., Muramatsu, Hiromi, Nallagatla, Subba R., Bevilacqua, Philip C., Sansing, Lauren H., Weissman, Drew, Karikó, Katalin
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2010
Assuntos:
RNA
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2943593/
https://ncbi.nlm.nih.gov/pubmed/20457754
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkq347
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