Incorporation of pseudouridine into mRNA enhances translation by diminishing PKR activation

Previous studies have shown that the translation level of in vitro transcribed messenger RNA (mRNA) is enhanced when its uridines are replaced with pseudouridines; however, the reason for this enhancement has not been identified. Here, we demonstrate that in vitro transcripts containing uridine acti...

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Bibliografiska uppgifter
Huvudupphovsmän: Anderson, Bart R., Muramatsu, Hiromi, Nallagatla, Subba R., Bevilacqua, Philip C., Sansing, Lauren H., Weissman, Drew, Karikó, Katalin
Materialtyp: Artigo
Språk:Inglês
Publicerad: Oxford University Press 2010
Ämnen:
RNA
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2943593/
https://ncbi.nlm.nih.gov/pubmed/20457754
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkq347
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