Incorporation of pseudouridine into mRNA enhances translation by diminishing PKR activation

Previous studies have shown that the translation level of in vitro transcribed messenger RNA (mRNA) is enhanced when its uridines are replaced with pseudouridines; however, the reason for this enhancement has not been identified. Here, we demonstrate that in vitro transcripts containing uridine acti...

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Bibliografske podrobnosti
Main Authors: Anderson, Bart R., Muramatsu, Hiromi, Nallagatla, Subba R., Bevilacqua, Philip C., Sansing, Lauren H., Weissman, Drew, Karikó, Katalin
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2010
Teme:
RNA
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2943593/
https://ncbi.nlm.nih.gov/pubmed/20457754
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkq347
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