Nucleoside modifications in RNA limit activation of 2′-5′-oligoadenylate synthetase and increase resistance to cleavage by RNase L

The interferon-induced enzymes 2′-5′-oligoadenylate synthetase (OAS) and RNase L are key components of innate immunity involved in sensory and effector functions following viral infections. Upon binding target RNA, OAS is activated to produce 2′-5′-linked oligoadenylates (2-5A) that activate RNase L...

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Sonraí Bibleagrafaíochta
Main Authors: Anderson, Bart R., Muramatsu, Hiromi, Jha, Babal K., Silverman, Robert H., Weissman, Drew, Karikó, Katalin
Formáid: Artigo
Teanga:Inglês
Foilsithe: Oxford University Press 2011
Ábhair:
RNA
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3241635/
https://ncbi.nlm.nih.gov/pubmed/21813458
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkr586
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