Cell-Type-Specific Activation of the Oligoadenylate Synthetase–RNase L Pathway by a Murine Coronavirus

Previous studies have demonstrated that the murine coronavirus mouse hepatitis virus (MHV) nonstructural protein 2 (ns2) is a 2′,5′-phosphodiesterase that inhibits activation of the interferon-induced oligoadenylate synthetase (OAS)-RNase L pathway. Enzymatically active ns2 is required for efficient...

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Detalhes bibliográficos
Main Authors: Zhao, Ling, Birdwell, L. Dillon, Wu, Ashley, Elliott, Ruth, Rose, Kristine M., Phillips, Judith M., Li, Yize, Grinspan, Judith, Silverman, Robert H., Weiss, Susan R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2013
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3719824/
https://ncbi.nlm.nih.gov/pubmed/23698313
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00769-13
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