Activation of RNase L by Murine Coronavirus in Myeloid Cells Is Dependent on Basal Oas Gene Expression and Independent of Virus-Induced Interferon

The oligoadenylate synthetase (OAS)-RNase L pathway is a potent interferon (IFN)-induced antiviral activity. Upon sensing double-stranded RNA, OAS produces 2′,5′-oligoadenylates (2-5A), which activate RNase L. Murine coronavirus (mouse hepatitis virus [MHV]) nonstructural protein 2 (ns2) is a 2′,5′-...

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Pubblicato in:J Virol
Autori principali: Birdwell, L. Dillon, Zalinger, Zachary B., Li, Yize, Wright, Patrick W., Elliott, Ruth, Rose, Kristine M., Silverman, Robert H., Weiss, Susan R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2016
Soggetti:
Pathogenesis and Immunity
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4810646/
https://ncbi.nlm.nih.gov/pubmed/26739051
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.03036-15
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