Increased Erythropoiesis in Mice Injected With Submicrogram Quantities of Pseudouridine-containing mRNA Encoding Erythropoietin

Advances in the optimization of in vitro-transcribed mRNA are bringing mRNA-mediated therapy closer to reality. In cultured cells, we recently achieved high levels of translation with high-performance liquid chromatography (HPLC)-purified, in vitro-transcribed mRNAs containing the modified nucleosid...

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Detalhes bibliográficos
Main Authors: Karikó, Katalin, Muramatsu, Hiromi, Keller, Jason M, Weissman, Drew
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2012
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3345990/
https://ncbi.nlm.nih.gov/pubmed/22334017
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2012.7
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