Transfection of pseudouridine-modified mRNA encoding CPD-photolyase leads to repair of DNA damage in human keratinocytes: a new approach with future therapeutic potential

UVB irradiation induces harmful photochemical reactions, including formation of cyclobutane pyrimidine dimers (CPDs) in DNA. Accumulation of unrepaired CPD lesions causes inflammation, premature ageing and skin cancer. Photolyases are DNA repair enzymes that can rapidly restore DNA integrity in a li...

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Hauptverfasser: Boros, Gábor, Miko, Edit, Muramatsu, Hiromi, Weissman, Drew, Emri, Eszter, Rózsa, Dávid, Nagy, Georgina, Juhász, Attila, Juhász, István, van der Horst, Gijsbertus, Horkay, Irén, Remenyik, Éva, Karikó, Katalin, Emri, Gabriella
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3888937/
https://ncbi.nlm.nih.gov/pubmed/24211294
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jphotobiol.2013.09.010
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