Transfection of pseudouridine-modified mRNA encoding CPD-photolyase leads to repair of DNA damage in human keratinocytes: a new approach with future therapeutic potential

UVB irradiation induces harmful photochemical reactions, including formation of cyclobutane pyrimidine dimers (CPDs) in DNA. Accumulation of unrepaired CPD lesions causes inflammation, premature ageing and skin cancer. Photolyases are DNA repair enzymes that can rapidly restore DNA integrity in a li...

Cur síos iomlán

Na minha lista:
Sonraí Bibleagrafaíochta
Main Authors: Boros, Gábor, Miko, Edit, Muramatsu, Hiromi, Weissman, Drew, Emri, Eszter, Rózsa, Dávid, Nagy, Georgina, Juhász, Attila, Juhász, István, van der Horst, Gijsbertus, Horkay, Irén, Remenyik, Éva, Karikó, Katalin, Emri, Gabriella
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2013
Ábhair:
Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3888937/
https://ncbi.nlm.nih.gov/pubmed/24211294
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jphotobiol.2013.09.010
Clibeanna: Cuir Clib Leis
Gan Chlibeanna, Bí ar an gcéad duine leis an taifead seo a chlibeáil!

Míreanna Comhchosúla