Transfection of pseudouridine-modified mRNA encoding CPD-photolyase leads to repair of DNA damage in human keratinocytes: a new approach with future therapeutic potential

UVB irradiation induces harmful photochemical reactions, including formation of cyclobutane pyrimidine dimers (CPDs) in DNA. Accumulation of unrepaired CPD lesions causes inflammation, premature ageing and skin cancer. Photolyases are DNA repair enzymes that can rapidly restore DNA integrity in a li...

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Main Authors: Boros, Gábor, Miko, Edit, Muramatsu, Hiromi, Weissman, Drew, Emri, Eszter, Rózsa, Dávid, Nagy, Georgina, Juhász, Attila, Juhász, István, van der Horst, Gijsbertus, Horkay, Irén, Remenyik, Éva, Karikó, Katalin, Emri, Gabriella
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3888937/
https://ncbi.nlm.nih.gov/pubmed/24211294
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jphotobiol.2013.09.010
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