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Elucidation of the active conformation of the amino terminus of receptor-bound secretin using intramolecular disulfide bond constraints

Family B G protein-coupled receptors include several potentially important drug targets, yet our understanding of the molecular basis of ligand binding to and activation of these receptors is incomplete. While NMR and crystal structures exist for peptide ligand-associated amino-terminal domains of s...

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書誌詳細
主要な著者: Dong, Maoqing, Pinon, Delia I., Bordner, Andrew J., Miller, Laurence J.
フォーマット: Artigo
言語:Inglês
出版事項: 2010
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2943047/
https://ncbi.nlm.nih.gov/pubmed/20813522
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2010.08.062
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