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Refinement of the pharmacophore of an agonist ligand of the secretin receptor using conformationally-constrained cyclic hexapeptides
There is a compelling need for the development of small molecule agonists acting at family B G protein-coupled receptors. A possible lead for the development of such drugs was reported when it was recognized that sequences endogenous to the amino terminus of the secretin receptor and certain other r...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2872052/ https://ncbi.nlm.nih.gov/pubmed/20214947 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.peptides.2010.02.024 |
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