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Refinement of the pharmacophore of an agonist ligand of the secretin receptor using conformationally-constrained cyclic hexapeptides

There is a compelling need for the development of small molecule agonists acting at family B G protein-coupled receptors. A possible lead for the development of such drugs was reported when it was recognized that sequences endogenous to the amino terminus of the secretin receptor and certain other r...

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Bibliografski detalji
Glavni autori: Dong, Maoqing, Narang, Pooja, Pinon, Delia I., Bordner, Andrew J., Miller, Laurence J.
Format: Artigo
Jezik:Inglês
Izdano: 2010
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2872052/
https://ncbi.nlm.nih.gov/pubmed/20214947
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.peptides.2010.02.024
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