Lactam Constraints Provide Insights into the Receptor-Bound Conformation of Secretin and Stabilize a Receptor Antagonist

The natural ligands for family B G protein-coupled receptors are moderate length linear peptides having diffuse pharmacophores. The amino-terminal regions of these ligands are critical for biological activity, with their amino-terminal truncation leading to production of orthosteric antagonists. The...

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Bibliographische Detailangaben
Hauptverfasser: Dong, Maoqing, Te, Jerez A., Xu, Xiequn, Wang, Jinhui, Pinon, Delia I., Storjohann, Laura, Bordner, Andrew J., Miller, Laurence J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3177990/
https://ncbi.nlm.nih.gov/pubmed/21851058
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi2008036
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