A Fluopol-ABPP HTS Assay to Identify PAD Inhibitors

Protein Arginine Deiminase (PAD) activity is dysregulated in numerous diseases, e.g., Rheumatoid Arthritis. Herein we describe the development of a fluorescence polarization-Activity Based Protein Profiling (fluopol-ABPP) based high throughput screening assay that can be used to identify PAD-selecti...

Volledige beschrijving

Bewaard in:
Bibliografische gegevens
Hoofdauteurs: Knuckley, Bryan, Jones, Justin E., Bachovchin, Daniel A., Slack, Jessica, Causey, Corey P., Brown, Steven J., Rosen, Hugh, Cravatt, Benjamin F., Thompson, Paul R.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2010
Onderwerpen:
Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2943038/
https://ncbi.nlm.nih.gov/pubmed/20740228
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c0cc02634d
Tags: Voeg label toe
Geen labels, Wees de eerste die dit record labelt!

Gelijkaardige items