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Profiling Protein Arginine Deiminase 4 (PAD4): A novel screen to identify PAD4 inhibitors

Protein Arginine Deiminase 4 (PAD4) has emerged as a leading target for the development of a Rheumatoid Arthritis (RA) pharmaceutical. Herein, we describe the development of a novel screen for PAD4 inhibitors that is based on a PAD4-targeted Activity-Based Protein Profiling reagent, denoted Rhodamin...

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Detalhes bibliográficos
Main Authors: Knuckley, Bryan, Luo, Yuan, Thompson, Paul R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2267747/
https://ncbi.nlm.nih.gov/pubmed/17964793
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2007.10.021
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