Substrate specificity and kinetic studies of PADs 1, 3, and 4 identify potent and selective inhibitors of Protein Arginine Deiminase 3

Protein citrullination has been shown to regulate numerous physiological pathways (e.g., the innate immune response and gene transcription), and is, when dysregulated, known to be associated with numerous human diseases, including cancer, rheumatoid arthritis, and multiple sclerosis. This modificati...

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Bibliographic Details
Main Authors: Knuckley, Bryan, Causey, Corey P., Jones, Justin E., Bhatia, Monica, Dreyton, Christina J., Osborne, Tanesha, Takahara, Hidenari, Thompson, Paul R.
Format: Artigo
Language:Inglês
Published: 2010
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2884139/
https://ncbi.nlm.nih.gov/pubmed/20469888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi100363t
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