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An improved synthesis of haloaceteamidine-based inactivators of protein arginine deiminase 4 (PAD4)
Protein arginine deiminase 4 (PAD4) is an enzyme that hydrolyzes peptidyl arginine residues to form citrulline and ammonia. This enzyme has been implicated in several disease states, e.g. rheumatoid arthritis, and therefore represents a unique target for the development of a novel therapeutic. A sol...
Tallennettuna:
| Päätekijät: | , |
|---|---|
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
2008
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2597826/ https://ncbi.nlm.nih.gov/pubmed/19587776 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tetlet.2008.05.021 |
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