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The Development and Use of Clickable Activity Based Protein Profiling Agents for Protein Arginine Deiminase 4

The Protein Arginine Deiminases (PAD), which catalyze the hydrolysis of peptidyl-arginine to form peptidyl-citrulline, are potential targets for the development of a Rheumatoid Arthritis (RA) therapeutic, as well as other human diseases including colitis and cancer. Additionally, these enzymes, and...

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Autors principals: Slack, Jessica L., Causey, Corey P., Luo, Yuan, Thompson, Paul R.
Format: Artigo
Idioma:Inglês
Publicat: 2011
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3098906/
https://ncbi.nlm.nih.gov/pubmed/21265574
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb1003515
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