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Protein Arginine Deiminase 4: Evidence for a reverse protonation mechanism

The presumed role of an overactive Protein Arginine Deiminase 4 (PAD4) in the pathophysiology of rheumatoid arthritis (RA) suggests that PAD4 inhibitors could be used to treat an underlying cause of RA, potentially offering a mechanism to stop further disease progression. Thus, the development of su...

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Hlavní autoři: Knuckley, Bryan, Bhatia, Monica, Thompson, Paul R.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2007
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2212595/
https://ncbi.nlm.nih.gov/pubmed/17497940
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi700095s
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