A FluoPol-ABPP PAD2 High-Throughput Screen Identifies the First Calcium Site Inhibitor Targeting the PADs

[Image: see text] The protein arginine deiminases (PADs) catalyze the post-translational hydrolysis of peptidyl-arginine to form peptidyl-citrulline in a process termed deimination or citrullination. PADs likely play a role in the progression of a range of disease states because dysregulated PAD act...

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Bibliografiske detaljer
Main Authors: Lewallen, Daniel M., Bicker, Kevin L., Madoux, Franck, Chase, Peter, Anguish, Lynne, Coonrod, Scott, Hodder, Peter, Thompson, Paul R.
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society 2014
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4108211/
https://ncbi.nlm.nih.gov/pubmed/24467619
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb400841k
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