RNA helicase A is a DNA-binding partner for EGFR-mediated transcriptional activation in the nucleus

EGF induces the translocation of EGF receptor (EGFR) from the cell surface to the nucleus where EGFR activates gene transcription through its binding to an AT-rich sequence (ATRS) of the target gene promoter. However, how EGFR, without a DNA-binding domain, can bind to the gene promoter is unclear....

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Bibliographische Detailangaben
Hauptverfasser: Huo, Longfei, Wang, Ying-Nai, Xia, Weiya, Hsu, Sheng-Chieh, Lai, Chien-Chen, Li, Long-Yuan, Chang, Wei-Chao, Wang, Yan, Hsu, Ming-Chuan, Yu, Yung-Luen, Huang, Tzu-Hsuan, Ding, Qingqing, Chen, Chung-Hsuan, Tsai, Chang-Hai, Hung, Mien-Chie
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2010
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2941329/
https://ncbi.nlm.nih.gov/pubmed/20802156
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1000743107
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