Nuclear EGFR Suppresses Ribonuclease Activity of Polynucleotide Phosphorylase through DNAPK-mediated Phosphorylation at Serine 776

Nuclear existence of epidermal growth factor receptor (EGFR) has been documented for more than two decades. Resistance of cancer to radiotherapy is frequently correlated with elevated EGFR expression, activity, and nuclear translocation. However, the role of nuclear EGFR (nEGFR) in radioresistance o...

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Detalhes bibliográficos
Main Authors: Yu, Yung-Luen, Chou, Ruey-Hwang, Wu, Chia-Han, Wang, Ying-Nai, Chang, Wei-Jung, Tseng, Yen-Ju, Chang, Wei-Chao, Lai, Chien-Chen, Lee, Hong-Jen, Huo, Longfei, Chen, Chung-Hsuan, Hung, Mien-Chie
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3438934/
https://ncbi.nlm.nih.gov/pubmed/22815474
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.358077
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