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An essential role of PRMT1-mediated EGFR methylation in EGFR activation by ribonuclease 5

Methylation at Arg198 and Arg200 residues of the EGFR extracellular domain by PRMT1 have been demonstrated to enhance EGFR activation by the canonical ligands, EGF and TGFα. On the other hand, RNase 5 was identified as a new ligand of EGFR recently. However, the interplay between EGFR methylation an...

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Detalhes bibliográficos
Publicado no:Am J Cancer Res
Main Authors: Wang, Wei-Jan, Hsu, Jung-Mao, Wang, Ying-Nai, Lee, Heng-Huan, Yamaguchi, Hirohito, Liao, Hsin-Wei, Hung, Mien-Chie
Formato: Artigo
Idioma:Inglês
Publicado em: e-Century Publishing Corporation 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6356926/
https://ncbi.nlm.nih.gov/pubmed/30755821
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