PRMT1-mediated methylation of the EGF receptor regulates signaling and cetuximab response

Posttranslational modifications to the intracellular domain of the EGFR are known to regulate EGFR functions; however, modifications to the extracellular domain and their effects remain relatively unexplored. Here, we determined that methylation at R198 and R200 of the EGFR extracellular domain by p...

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Udgivet i:J Clin Invest
Main Authors: Liao, Hsin-Wei, Hsu, Jung-Mao, Xia, Weiya, Wang, Hung-Ling, Wang, Ying-Nai, Chang, Wei-Chao, Arold, Stefan T., Chou, Chao-Kai, Tsou, Pei-Hsiang, Yamaguchi, Hirohito, Fang, Yueh-Fu, Lee, Hong-Jen, Lee, Heng-Huan, Tai, Shyh-Kuan, Yang, Mhu-Hwa, Morelli, Maria P., Sen, Malabika, Ladbury, John E., Chen, Chung-Hsuan, Grandis, Jennifer R., Kopetz, Scott, Hung, Mien-Chie
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2015
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4665782/
https://ncbi.nlm.nih.gov/pubmed/26571401
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI82826
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