Oncogenic functions of Gli in pancreatic adenocarcinoma are supported by its PRMT1-mediated methylation

The oncogenic transcription factor Gli1 is a critical effector in the Hedgehog (Hh) pathway which is necessary for the development and progression of pancreatic ductal adenocarcinoma (PDAC). While TGF-β and K-Ras are known regulators of Gli1 gene transcription in this setting, it is not understood h...

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Veröffentlicht in:Cancer Res
Hauptverfasser: Wang, Yan, Hsu, Jung-Mao, Kang, Ya’an, Wei, Yongkun, Lee, Pei-Chih, Chang, Shing-Jyh, Hsu, Yi-Hsin, Hsu, Jennifer L., Wang, Hung-Ling, Chang, Wei-Chao, Li, Chia-Wei, Liao, Hsin-Wei, Chang, Shih-Shin, Xia, Weiya, Ko, How-Wen, Chou, Chao-Kai, Fleming, Jason B., Wang, Huamin, Hwang, Rosa F., Chen, Yue, Qin, Jun, Hung, Mien-Chie
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5135656/
https://ncbi.nlm.nih.gov/pubmed/27758883
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-16-0715
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