EGFR potentiates MCM7-mediated DNA replication through tyrosine phosphorylation of Lyn kinase in human cancers

EGFR initiates a signaling cascade that leads to DNA synthesis and cell proliferation, but its role in regulating DNA replication licensing is unclear. Here, we show that activated EGFR phosphorylates the p56 isoform of Lyn, p56(Lyn), at Y32, which then phosphorylates MCM7, a licensing factor critic...

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Detalhes bibliográficos
Main Authors: Huang, Tzu-Hsuan, Huo, Longfei, Wang, Ying-Nai, Xia, Weiya, Wei, Yongkun, Chang, Shih-Shin, Chang, Wei-Chao, Fang, Yueh-Fu, Chen, Chun-Te, Lang, Jing-Yu, Tu, Chun, Wang, Yan, Hsu, Ming-Chuan, Kuo, Hsu-Ping, Ko, How-Wen, Shen, Jia, Lee, Heng-Huan, Lee, Pei-Chih, Wu, Yun, Chen, Chung-Hsuan, Hung, Mien-Chie
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3703149/
https://ncbi.nlm.nih.gov/pubmed/23764002
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2013.04.027
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