EGFR potentiates MCM7-mediated DNA replication through tyrosine phosphorylation of Lyn kinase in human cancers

EGFR initiates a signaling cascade that leads to DNA synthesis and cell proliferation, but its role in regulating DNA replication licensing is unclear. Here, we show that activated EGFR phosphorylates the p56 isoform of Lyn, p56(Lyn), at Y32, which then phosphorylates MCM7, a licensing factor critic...

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Autors principals: Huang, Tzu-Hsuan, Huo, Longfei, Wang, Ying-Nai, Xia, Weiya, Wei, Yongkun, Chang, Shih-Shin, Chang, Wei-Chao, Fang, Yueh-Fu, Chen, Chun-Te, Lang, Jing-Yu, Tu, Chun, Wang, Yan, Hsu, Ming-Chuan, Kuo, Hsu-Ping, Ko, How-Wen, Shen, Jia, Lee, Heng-Huan, Lee, Pei-Chih, Wu, Yun, Chen, Chung-Hsuan, Hung, Mien-Chie
Format: Artigo
Idioma:Inglês
Publicat: 2013
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3703149/
https://ncbi.nlm.nih.gov/pubmed/23764002
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2013.04.027
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