The disruption of the rod-derived cone viability gene leads to photoreceptor dysfunction and susceptibility to oxidative stress

Rod-derived Cone Viability Factor is a thioredoxin-like protein which has therapeutic potential for rod-cone dystrophies such as retinitis pigmentosa (RP). Cone loss in rodent models of RP is effectively reduced by RdCVF treatment. Here we investigate the physiological role of RdCVF in the retina by...

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Main Authors: Cronin, Thérèse, Raffelsberger, Wolfgang, Lee-Rivera, Irene, Jaillard, Céline, Niepon, Marie-Laure, Kinzel, Bernd, Clérin, Emmanuelle, Petrosian, Andranik, Picaud, Serge, Poch, Olivier, Sahel, José-Alain, Léveillard, Thierry
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2010
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2933397/
https://ncbi.nlm.nih.gov/pubmed/20139892
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2010.2
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