The disruption of the rod-derived cone viability gene leads to photoreceptor dysfunction and susceptibility to oxidative stress

Rod-derived Cone Viability Factor is a thioredoxin-like protein which has therapeutic potential for rod-cone dystrophies such as retinitis pigmentosa (RP). Cone loss in rodent models of RP is effectively reduced by RdCVF treatment. Here we investigate the physiological role of RdCVF in the retina by...

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Autors principals: Cronin, Thérèse, Raffelsberger, Wolfgang, Lee-Rivera, Irene, Jaillard, Céline, Niepon, Marie-Laure, Kinzel, Bernd, Clérin, Emmanuelle, Petrosian, Andranik, Picaud, Serge, Poch, Olivier, Sahel, José-Alain, Léveillard, Thierry
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2010
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2933397/
https://ncbi.nlm.nih.gov/pubmed/20139892
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2010.2
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