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The disruption of the rod-derived cone viability gene leads to photoreceptor dysfunction and susceptibility to oxidative stress

Rod-derived Cone Viability Factor is a thioredoxin-like protein which has therapeutic potential for rod-cone dystrophies such as retinitis pigmentosa (RP). Cone loss in rodent models of RP is effectively reduced by RdCVF treatment. Here we investigate the physiological role of RdCVF in the retina by...

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Detalhes bibliográficos
Main Authors: Cronin, Thérèse, Raffelsberger, Wolfgang, Lee-Rivera, Irene, Jaillard, Céline, Niepon, Marie-Laure, Kinzel, Bernd, Clérin, Emmanuelle, Petrosian, Andranik, Picaud, Serge, Poch, Olivier, Sahel, José-Alain, Léveillard, Thierry
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2933397/
https://ncbi.nlm.nih.gov/pubmed/20139892
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2010.2
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