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Apollo contributes to G-overhang maintenance and protects leading-end telomeres

Mammalian telomeres contain a single-stranded 3′ overhang that is thought to mediate telomere protection. Here we identify the TRF2-interacting factor Apollo as a nuclease that contributes to the generation/maintenance of this overhang. The function of mouse Apollo was determined using Cre-mediated...

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書誌詳細
主要な著者: Wu, Peng, van Overbeek, Megan, Rooney, Sean, de Lange, Titia
フォーマット: Artigo
言語:Inglês
出版事項: 2010
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2929323/
https://ncbi.nlm.nih.gov/pubmed/20619712
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2010.06.031
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