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Removal of Shelterin Reveals the Telomere End-Protection Problem
The telomere end-protection problem is defined by the aggregate of DNA damage signaling and repair pathways that require repression at telomeres. To define the end-protection problem, we removed the whole shelterin complex from mouse telomeres through conditional deletion of TRF1 and TRF2 in nonhomo...
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| Main Authors: | , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2012
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3477646/ https://ncbi.nlm.nih.gov/pubmed/22556254 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1218498 |
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