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POT1 protects telomeres from a transient DNA damage response and determines how human chromosomes end
The hallmarks of telomere dysfunction in mammals are reduced telomeric 3′ overhangs, telomere fusions, and cell cycle arrest due to a DNA damage response. Here, we report on the phenotypes of RNAi-mediated inhibition of POT1, the single-stranded telomeric DNA-binding protein. A 10-fold reduction in...
Tallennettuna:
| Päätekijät: | , , , , |
|---|---|
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
2005
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1176460/ https://ncbi.nlm.nih.gov/pubmed/15973431 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600733 |
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