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POT1 protects telomeres from a transient DNA damage response and determines how human chromosomes end

The hallmarks of telomere dysfunction in mammals are reduced telomeric 3′ overhangs, telomere fusions, and cell cycle arrest due to a DNA damage response. Here, we report on the phenotypes of RNAi-mediated inhibition of POT1, the single-stranded telomeric DNA-binding protein. A 10-fold reduction in...

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Detaylı Bibliyografya
Asıl Yazarlar: Hockemeyer, Dirk, Sfeir, Agnel J, Shay, Jerry W, Wright, Woodring E, de Lange, Titia
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2005
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC1176460/
https://ncbi.nlm.nih.gov/pubmed/15973431
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600733
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