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Apollo contributes to G-overhang maintenance and protects leading-end telomeres
Mammalian telomeres contain a single-stranded 3′ overhang that is thought to mediate telomere protection. Here we identify the TRF2-interacting factor Apollo as a nuclease that contributes to the generation/maintenance of this overhang. The function of mouse Apollo was determined using Cre-mediated...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2010
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2929323/ https://ncbi.nlm.nih.gov/pubmed/20619712 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2010.06.031 |
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