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Telomeric 3′ overhangs derive from resection by Exo1 and Apollo and fill-in by POT1b-associated CST

A 3′ overhang is critical for the protection and maintenance of mammalian telomeres. How these overhangs are generated and whether different processing steps modify telomeres synthesized by leading- and lagging-strand DNA replication was not known. Here we evaluate changes in the telomeric overhangs...

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Detalhes bibliográficos
Main Authors: Wu, Peng, Takai, Hiroyuki, de Lange, Titia
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3392515/
https://ncbi.nlm.nih.gov/pubmed/22748632
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2012.05.026
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