53BP1/Rif1/Shieldin counteract DSB resection through CST/Polα-dependent fill-in

Resection of double-strand breaks (DSBs) dictates the choice between Homology-Directed Repair (HDR), which requires a 3′ overhang, and classical Non-Homologous End Joining (c-NHEJ), which can join unresected ends(1,2). BRCA1 mutant cancers show minimal DSB resection, rendering them HDR deficient and...

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Publicat a:Nature
Autors principals: Mirman, Zachary, Lottersberger, Francisca, Takai, Hiroyuki, Kibe, Tatsuya, Gong, Yi, Takai, Kaori, Bianchi, Alessandro, Zimmermann, Michal, Durocher, Daniel, de Lange, Titia
Format: Artigo
Idioma:Inglês
Publicat: 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6072559/
https://ncbi.nlm.nih.gov/pubmed/30022158
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-018-0324-7
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