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Protein phosphatase 1 acts as a RIF1 effector to suppress DSB resection prior to Shieldin action
DNA double-strand breaks (DSBs) are repaired mainly by non-homologous end joining (NHEJ) or homologous recombination (HR). RIF1 negatively regulates resection through the effector Shieldin, which associates with a short 3′ single-stranded DNA (ssDNA) overhang by the MRN (MRE11-RAD50-NBS1) complex, t...
שמור ב:
| הוצא לאור ב: | Cell Rep |
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| Main Authors: | , , , , , |
| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
Cell Press
2021
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8293623/ https://ncbi.nlm.nih.gov/pubmed/34260925 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2021.109383 |
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