Protein phosphatase 1 acts as a RIF1 effector to suppress DSB resection prior to Shieldin action

DNA double-strand breaks (DSBs) are repaired mainly by non-homologous end joining (NHEJ) or homologous recombination (HR). RIF1 negatively regulates resection through the effector Shieldin, which associates with a short 3′ single-stranded DNA (ssDNA) overhang by the MRN (MRE11-RAD50-NBS1) complex, t...

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Veröffentlicht in:Cell Rep
Hauptverfasser: Isobe, Shin-Ya, Hiraga, Shin-ichiro, Nagao, Koji, Sasanuma, Hiroyuki, Donaldson, Anne D., Obuse, Chikashi
Format: Artigo
Sprache:Inglês
Veröffentlicht: Cell Press 2021
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8293623/
https://ncbi.nlm.nih.gov/pubmed/34260925
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2021.109383
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