Rif1 acts through Protein Phosphatase 1 but independent of replication timing to suppress telomere extension in budding yeast

The Rif1 protein negatively regulates telomeric TG repeat length in the budding yeast Saccharomyces cerevisiae, but how it prevents telomere over-extension is unknown. Rif1 was recently shown to control DNA replication by acting as a Protein Phosphatase 1 (PP1)-targeting subunit. Therefore, we inves...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Nucleic Acids Res
Prif Awduron: Kedziora, Sylwia, Gali, Vamsi K, Wilson, Rosemary HC, Clark, Kate RM, Nieduszynski, Conrad A, Hiraga, Shin-ichiro, Donaldson, Anne D
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Oxford University Press 2018
Pynciau:
Genome Integrity, Repair and Replication
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5934629/
https://ncbi.nlm.nih.gov/pubmed/29529242
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky132
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