Rif1 acts through Protein Phosphatase 1 but independent of replication timing to suppress telomere extension in budding yeast

The Rif1 protein negatively regulates telomeric TG repeat length in the budding yeast Saccharomyces cerevisiae, but how it prevents telomere over-extension is unknown. Rif1 was recently shown to control DNA replication by acting as a Protein Phosphatase 1 (PP1)-targeting subunit. Therefore, we inves...

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Dettagli Bibliografici
Pubblicato in:Nucleic Acids Res
Autori principali: Kedziora, Sylwia, Gali, Vamsi K, Wilson, Rosemary HC, Clark, Kate RM, Nieduszynski, Conrad A, Hiraga, Shin-ichiro, Donaldson, Anne D
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2018
Soggetti:
Genome Integrity, Repair and Replication
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5934629/
https://ncbi.nlm.nih.gov/pubmed/29529242
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky132
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