Rif1 acts through Protein Phosphatase 1 but independent of replication timing to suppress telomere extension in budding yeast

The Rif1 protein negatively regulates telomeric TG repeat length in the budding yeast Saccharomyces cerevisiae, but how it prevents telomere over-extension is unknown. Rif1 was recently shown to control DNA replication by acting as a Protein Phosphatase 1 (PP1)-targeting subunit. Therefore, we inves...

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Detalles Bibliográficos
Publicado en:Nucleic Acids Res
Autores principales: Kedziora, Sylwia, Gali, Vamsi K, Wilson, Rosemary HC, Clark, Kate RM, Nieduszynski, Conrad A, Hiraga, Shin-ichiro, Donaldson, Anne D
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2018
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5934629/
https://ncbi.nlm.nih.gov/pubmed/29529242
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky132
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