Phosphorylation by Casein Kinase I Promotes the Turnover of the Mdm2 Oncoprotein via the SCF(β-TRCP) Ubiquitin Ligase

Mdm2 is the major negative regulator of the p53 pathway. Here we report that Mdm2 is rapidly degraded after DNA damage and that phosphorylation of Mdm2 by Casein Kinase I (CKI) at multiple sites triggers its interaction with, and subsequent ubiquitination and destruction, by SCF(β-TRCP). Inactivatio...

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Main Authors: Inuzuka, Hiroyuki, Tseng, Alan, Gao, Daming, Zhai, Bo, Zhang, Qing, Shaik, Shavali, Wan, Lixin, Ang, Xiaolu L., Mock, Caroline, Yin, Haoqiang, Stommel, Jayne M., Gygi, Steven, Lahav, Galit, Asara, John, Jim Xiao, Zhi-Xiong, Kaelin, William G., Harper, J. Wade, Wei, Wenyi
Formato: Artigo
Idioma:Inglês
Publicado: 2010
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2923652/
https://ncbi.nlm.nih.gov/pubmed/20708156
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2010.06.015
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